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Recruitment of case owners, and a responsible teacher with a background in data science for the USE learning line Digital Twins in Healthcare

jan de boer My name is Jan de Boer, professor of BioInterface Science at BME and I am developing the USE learning line “Digital Twin in Healthcare together with my colleagues from the TU/e departments of Biomedical Engineering (BME), Mechanical Engineering (ME), Industrial Engineering and Innovation Science (IE & IS), and the faculty of Medicine at the UMC Utrecht.

This USE LL aims to teach engineers about the role of technology in the healthcare system, the impact of technology on patients, and the role  of the engineer in this ecosystem. Digital Twins are the scaffolds on which we build a curriculum.

We use a modular approach. Each module is based on a clinical case which is organized by a case owner, who is a TU/e teacher who brings in her/his favorite digital twin topic. We already have several cases, for example, atrial fibrillation, metabolic profiling in diabetes, scoliosis surgery and medical imaging using catheters. However, we are actively recruiting case owners. Each case owner brings along a clinical liaison, a company liaison and organizes the tutors needed to run the USE case. Challenge-based learning (CBL) is our main teaching strategy.

The USE LL comprises of three modules, each of 5 ECTS: Conceiving, Designing and Operating/Implementing. Each module has a responsible teacher. The conceiving phase is coordinated by Burcu Gumuscu (BME) who will design the learning methods to bring the pieces of the puzzle to the students, the stake holders, the technology, and the medical problem. The Operating/Implementation phase is coordinated by Wybo Houkes (IE & IS) who will show the students how a digital twin can be used off campus: with patients, in hospitals, and as part of a company portfolio.

For the second phase of this USE LL (Designing phase) we are looking for a responsible teacher with a background in the data science of Digital Twins, with experience in modeling, machine learning, AI, and databases. A creative thinker who can link her/his expertise to coordinate the data science of the clinical cases in collaboration with the case owners and the responsible teachers of the Conceiving and Operating/Implementing phase.

USE LL Digital Twin in Healthcare received a grant from the Educational Innovation fund, and we have recruited a full-time project manager for the duration of two years to support the USE LL in the development of the educational material. Innovation Space is also involved in the development of the curriculum. In the first year, this learning line will receive 100 students, but we expect to grow in the future. Revenues of teaching are proportionally distributed among the departments.

If you are interested in either the role as case owner or responsible teacher, please contact me at This email address is being protected from spambots. You need JavaScript enabled to view it.

New article out in Scientific Reports!


Our recent, collaborative effort to establish an approach to identify a universal set of genes that regulate the material-induced phenotypical response of hMSCs has just been published in Scientific Reports! 

In this manuscript, we obtained proof of principle for the correlation between image-based cell features and cell signalling and 11 basic cell shape features. There is likely an opportunity for mechanistic information within cell organelle shape and associated correlations with phenotype. The approach can be taken much further and feed into the creation of large-scale computational models which describe biomaterial surface design, cell shape and cell phenotype. This approach is referred to as Quantitative Structure–Activity Relationships (QSAR) and is widely used to model the biological activity of pharmaceutical compounds. It allows predicting the biological efect of untested compounds and thus narrowing down the search space.

Read the full article here.

We are recruiting!

Assistant/Associate Professor Mechanics of Interactive Biomaterials

There is a new, exciting opening for an Assistant/Associate Professor in the Biomedical Engineering Department in the field of mechanics of interactive biomaterials. The position concentrates on meso-scale mechanics of materials and experimental approaches to design novel biomaterials that interact with tissues and organs.

Learn more about this oppurtunity, our deparment and what it is like to work at the TU/e here

Jesse wins the SenseUs2020 biosensor competition!

SenseUs2020 BioSensor Competitition 


Last week, our masters student Jesse Jagers competed in the SenseUs2020 event with his TU/e team TEST and won the Creativity Award. 

SensUs 2020 has challenged talented student teams from all over the world to develop innovative biosensing systems for the measurement unbound valproate, a biological drug that is used to treat epilepsy.15 international student teams presented their work online on August 28, in an event full of students, industry experts, patients and healthcare professionals. Check the event website here if you are interested in participicating next year.

Congratulations Jesse! We are excited to have you in our group!


  • BiS-Biointerface Science in Regenerative Medicine
  • TU/e Department of Biomedical Engineering
Eindhoven University of Technology
PO Box 513
5600 MB, Eindhoven
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