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Visiting scientist

Giulia Sivelli

Giulia Sivelli

Giulia Sivelli (Royal Veterinary College, London) has completed her MSc. in in Molecular Biology of The Cell, University of Milan, Italy (2013-2016) and BSc. in Animal Welfare and Husbandry, University of Milan, Italy (2010-2013). Currently , she is a Ph.D. candidate within the Marie Skolwdoska Curie ITN Tendon Therapy Train. Tendon Biology Group Department of Clinical Science and Services Royal Veterinary College London under the supervison of Dr. Jayesh Dudhia and Prof. Roger K. Smith. She is working on 'Profiling Extracellular Vesicles derived from Equine Mesenchymal Stem Cells and Tendon Derived Cells for Tendon Regeneration'. The main goal of this project is to investigate the equine Bone Marrow derived Mesenchymal Stem Cell (BM-MSCs) and Tendon Derived Cell (TDCs) secretome to inform the design of novel cell-free therapies for a successful tendon healing toward efficient tissue regeneration. This will be achieved by using an in vitro model of equine tendon inflammation, serum free culture conditions and surface topography stimulation of equine MSCs and TDCs to induce the expression of Extracellular Vesicles (EVs) with regenerative and anti-inflammatory potential.

Students

Niels Smolders

Niels Smolders

I am completing my medical sciences and technology bachelor degree at Eindhoven University of Technology. During my bachelor, I developed a great interest in tissue engineering because of its enormous potential for developing organ/tissue models and new products. I chose to do my BEP (bachelor end project) at the BioInterface Science group because I thought that it would be a great experience to connect my interest in tissue engineering with actual research in the same field.

Thomas Woud

Thomas Woud

I am a third year student at the TU Eindhoven currently working on my bachelor in Biomedical technology. Ever since I was young I had a wish for a career in which I could make people’s lives better. Combining that wish with my love for sciences such as biology, physics, and chemistry led me to choose a path in biomedical engineering. In my years at the university I developed a particular interest in regenerative medicine. For my bachelor thesis I will thus be working with the bio-interface science research group lead by Jan de Boer, which focuses on understanding the complex interplay between cell behavior and biointerfaces for applications in regenerative medicine. During my time with the group, I hope to learn what it takes to conduct a real scientific research and experience the victories and downfalls it brings with it.

Naomie Amsing

Naomie Amsing

I started my university life in 2016 with a bachelor in Biomedical Engineering at the Eindhoven University of Technology. The coming two months will be dominated by performing my bachelor end project within Jan de Boer’s group. I am still to decide upon a research question, but I am interested in the effects of an implant’s mechanical properties on the regenerated tissue. I am very much looking forward to working together with the amazing people within the group and learning new skills. After receiving my bachelor’s degree next year, I will start a master program in Regenerative Medicine and Technology.

nadia takke

Nadia Takke

I'm a third year student at the TU / e in Medical Science and Engineering. This quartile, I'm starting my BEP in Regenerative Engineering with the group of Jan de Boer. We will focus on the influence on topography on cell behavior. I'm excited to broaden my knowledge on cell-material interface and use my knowledge from the past three years for current research.

bas voermans

Bas Voermans

Bas Voermans is a bachelor student at Biomedical Engineering, Eindhoven University of Technology (TU/e), with electives in computational biology and imaging, hailing originally from Rotterdam. During his bachelor he was drawn mostly to the part of the biomedical engineering faculty that involve the use of programming to solve problems in the biomedical field. He will be conducting his bachelor end project(BEP) at the BioInterface Science (BiS) group of Regenerative Medicine at  TU/e. During his BEP he will be researching the influence of surface topography on cell behavior first hand along with several other BEP students whilst still having an individual research goal, the main goal of this project is gaining familiarity of how research is performed in one of the research groups of TU/e as well as tackling a research problem presented by the group in a two month period.

marc mazur

Marc Mazur

I am a dual-degree medical student from Utrecht with a passion for biomedical engineering and exploring what mechanobiology can mean for the clinical side. During my research internship at TUe, I want to delineate the effects of stiffness from surface geometry, on cellular proliferation. To do this I will be coating a topographical surface with hydrogel of known selected stiffness – so that cells can still sense the ‘implicit’ surface geometry underneath the hydrogel. The de Boer lab is already investigating the effect of direct contact with surface topography. I will also start with an experiment on hydrogel without topography as a baseline. With the collaboration, I will be able to compare hydrogels, hydrogel-coated and uncoated topographical surfaces and their effect on morphology and proliferation. The results will hopefully indicated a surface topography-hydrogel combination that either stimulates proliferation (for the purposes of tissue engineering or implantable devices) or inhibits it (for the purposes of cancer therapeutics or diagnostics).

Staff alumni

  • Aurélie Carlier, 2018, Assistant Prof at cBITE (Cell Biology Inspired Tissue Engineering)
  • Dennie Hebels, 2018, Project Manager at cBITE (Cell Biology Inspired Tissue Engineering)
  • Marloes Kamphuis, 2018, Lab Manager at cBITE (Cell Biology Inspired Tissue Engineering)
  • Nadia Roumans, 2018, Lab Technician at cBITE (Cell Biology Inspired Tissue Engineering)
  • Linfeng (Joseph) Li, 2018, PhD student: Trophoblast stem cell differentiation via TopoChip Technology.
  • Nick Beijer, 2018, PhD student: Topographically enhanced cell culture systems to induce and monitor mechanobiology.
  • Frits Hulshof, 2016, PhD student: Topochip: Technology for Instructing Cell Fate and Morphology via Designed Surface Topography.
  • Jenny Brinkmann, 2016, PhD student: Dynamic bioactive surfaces for cells using cucurbiturils.
  • Maqsood (Max) Ahmed, 2014, postdoc: High-throughput screening of fiber spun scaffolds.
  • Anouk Mentink, 2014,  research technician and lab manager.
  • Eelco Fennema, 2014, PhD student: An analysis of trauma and its solutions in bone tissue engineering.  
  • Bach Le Quang, 2014, PhD student:Decellularized cartilage matrix  as an alternative for demineralized bone matrix.
  • Nathalie Groen, 2014, PhD student: High throughput screening of bone graft materials.
  • Vanessa LaPointe, 2014, postdoc: Molecular biology in 3D.
  • Karolina Janeczek, 2013, PhD student: Endothelial differentiation of mesenchymal stem cells.
  • Hemant Unadkat, 2012, PhD student: The effect of topography on cell behaviour.
  • Joyce Doorn, 2012, PhD student: Paracrine signaling of human mesenchymal stem cells.
  • Anindita Ganguly, 2012, PhD student: Clinical translation of bone tissue engineering.
  • Ana Barradas, 2012, PhD student: Molecular mechanism of osteo-induction.
  • Hugo Andre Alves, 2010, PhD student, Ageing and human mesenchymal stem cells.
  • Jun Liu, 2009, PhD student, Bioluminescent imaging in tissue engineering.
  • Jojanneke Jukes, 2009, PhD student, Embryonic stem cells in cartilage tissue engineering.
  • Hugo Fernandes, 2009, PhD student and postdoc,The role of extracellular matrix in bone tissue engineering.
  • Ram Siddappa, 2008, PhD student, Protein kinase A signaling in bone tissue engineering.
  • Sanne Both, 2008, PhD student, Mouse embryonic stem cells in bone tissue engineering.
  • Ruud Licht, 2007, research technician, Target discovery for bone-regeneration.

 

Student alumni

  • Floris Honig,2018, Assessing the expression level of mechanical sensitive markers on topographical surfaces.
  • Fred Zhaoji Shen,2018, Construction a computational model linking extracellular matrix properties to biomedical signaling pathway.
  • Bianca Lourens,2018, Imaging capabilities to explore possibilities in distinguishing monocytes from healthy donors and monocytes exposed to proinflammatory factors.
  • Adrián Seijas Gamardo,2018, Cell communication between mesenchymal stem cells and monocytes/macrophages
  • Iris Wijnen,2018, Mechanotransduction pathways involved in topography-induced cell behavior
  • Francesca Bolk,2018, Monocyte migration in response to proinflammatory factors
  • Jingyun Wu,2018, the response of flexor tendon derived cells to TGF-β2 exposure,
  • Rianne Helgers,2018, The response of flexor tendon derived cells to TGF-β2 exposure
  • Zarina Nauryzgaliyeva, 2017: Braille code for cells: hMSCs protective response to cellular deformation induced by surface topographies
  • Estela Arteaga, 2017: Study of the effect of topographies in human mesenchymal stem cells and cardiomyocyte size and proliferation
  • Rika Reihs, 2017: Digitalizing life at the interface: Finding the missing links between biomaterial properties and biological pathways
  • Ben van der Veer, 2017: Changing epigenetics with a Braille script for cells: The effect of micro topography on global histone acetylation and methylation in human mesenchymal stem cells
  • Bram van Steen, 2017: Live Cell imaging reveals dynamic cell response to microstructured topographies
  • Luc Sondorp, 2016: Gene regulatory effects of bone graft materials on osteoblasts
  • Jéré van Lente, 2016: Topography screening with mesenchymal stem cells

 

Visiting scientist alumni

  • Laurence Burroughs, 2018, University of Nottingham, UK
  • Dominika Berdecka, 2018, 3B's Research Group, Marie Sklodowska-Curie Innovative Training Network "Tendon Therapy Train", University of Minho, Portugal
  • Britta Koch, 2017, Nottingham University, UK

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Contact

  • BiS-Biointerface Science in Regenerative Medicine
  • TU/e Department of Biomedical Engineering
Eindhoven University of Technology
PO Box 513
5600 MB, Eindhoven
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