Understanding the Effects of Dynamic Mechanotransduction on Stem Cell Signaling and Differentiation Using Artificial, Magnetically Actuated Cilia
Roel Kooi received his BSc degree in Molecular Life Sciences in 2017 from Wageningen University, after completing his thesis research in the group of Prof. Aldrik Velders on micron-scale functionalization of microfluidic channels for sensing purposes. He did his MSc studies of Molecular Life Sciences also at Wageningen University (2017-2020), with a thesis in the group of Prof. Jasper van der Gucht on unraveling mechanical convolution in indentation experiments by comparing experimental indentation results to finite element simulations. As a part of his MSc curriculum, he completed a six month internship at the university of Ulm, Germany, working in the group of prof. Alexander Kühne on the synthesis of colloidal particles exhibiting Thermally Activated Delayed Fluorescence. Roel is working as a PhD candidate in the research group of Prof. Jaap den Toonder in the Microsystems section, in close collaboration with Prof. Jan de Boer and the BioInterface Science group. Roel's research focuses on the influence of dynamic mechanotransduction on the development of stem cells, aiming for a better understanding of stem cell differentiation for regenerative therapy purposes.
High-throughput Screening of Biomaterials Using Machine Learning
Jasper did his bachelor and master in biomedical engineering at the university of technology in Eindhoven, where he specialized in supramolecular chemistry. He focused on the self-assembly behavior of linear polymers which would fold into single-chain polymeric nanoparticles in water. These nanoparticles were used for enzyme mimicking in aqueous media. In 2020 he started as a PhD student in the group of Prof. Patricia Dankers, where he will be investigating the high-throughput screening of supramolecular biomaterials. This will be done in collaboration with researchers from the group of Prof. Jan de Boer.
Antonio van der Lande
Modeling ACL graft mechanics using Finite Element Method, as a first step in the development of the Digital Twin of ACL grafts
Hi, my name is Antonio van der Lande. I am a second-year Biomedical Engineering master student at the TU/e. I have finished my bachelor degree with a Bachelor End Project in which I modelled the mechanics of an anti-decubitus mattress for prevention of pressure ulcers. This is also where my main interest lies, capturing in vivo phenomena in a digital platform to perform in silico research. With the fast development of machine learning, in silico research is showing great promise, opening up the possibilities to make use of a Digital Twin in healthcare. Ultimately, I would like to contribute to the digital representation of the human body and thereby tackling clinical problems.
The Effect of (native) Topography on the Formation of Focal Adhesion and Actin Cytoskeleton Dynamics in MSCs and Tenocytes
Amy studies Regenerative Medicine and Technology at the TU/e and the University of Utrecht, which is a subtrack of the master Biomedical Engineering. Before that, she finished her bachelor degree Medical Sciences and Technology in 2018. She performed her master thesis on the development of a high-throughput screening device for the optimization of in vitro growth of renal cells in the Biomaterials group of prof. Patricia Dankers (2019-2020). Amy joined the BiS group in August, 2020, for her master internship. In this project, she focuses on the development of focal adhesions in tenocytes at different stages of passage and cultured on tendon-inspired topographies, to understand the fundamentals of this process over time.
Topographic approach to identify and validate macrophage genes, associated with breast implant associated anaplastic large cell lymphoma (BIA-ALCL)
Hello everyone, my name is Jesse Jägers and I am currently a first year Master student in Biomedical Engineering. For my Bachelor Thesis I investigated the orientational effect of tenocytes on different substrates under mechanical load. Here I already combined biology and technology which are two topics I am really passionate about. I want to continue this passion at BiS while also learning about computational methods for data analysis and new possibilities in the field of regenerative engineering. Ultimately I hope that, by combining all these topics, I can contribute in the improvement of immunotherapy.
Hi, I am Naomie, currently a first year Master student following the track “Regenerative Engineering”. I did by Bachelor Thesis also at the BiS group, and enjoyed my time there so much, I wanted to do my Master Thesis here as well. My main interest lies in the improvement of biomedical research by means of smarter design and better use of computer and in vitro models. I want to have a positive contribution to the growing field: I hope that ultimately better predictions can be made so that we can provide a higher chance of success, we can reduce animal testing and we can give regenerative research a boost!
Hello, my name is Emy Curvers and I am a first year master student Biomedical Engineering. During my bachelor I did my Bachelor End Project within the Cluster of Regenerative Engineering and Materials, Orthopedic Biomechanics. My project was mostly oriented at the interaction of tibial bone with biomaterials, in which I was particularly interested in the cell biology. In the BioInterface Science group there is more focus on cell biology, which is why I would like to do my master thesis in this group.
A Microfluidic System for Long-term Hepatocyte Culturing
Hello everyone my name is Joska Aerts and I am currently in my second year of the master Biomedical Engineering at the TU/e, at which I also achieved my bachelor in Medical Sciences and Engineering. In my bachelor, I mainly focused on tissue engineering and cell biological courses, during which I got interested in the BioInterface Science group. This group focuses on the subjects that I find interesting, but also gives the possibility to broaden my knowledge. For my master thesis, I will develop a microfluidic system for long-term hepatocyte culturing. I am very excited to work on this project in the BioInterface Science group!
Julia van den Beemd
Dendritic Cell Migration via Interchangeable Migration Modes
After graduating for my bachelor of Medical Sciences and Engineering, I started my masters Biomedical Engineering at the TU/e in September 2019. In my bachelor I mostly focused on tissue engineering and cell biological courses. The BioInterface Science group also focuses on disciplines that were not really covered in my bachelors program, which interested me to broaden my knowledge. During my first year as a masters student I will focus on following courses that will learn me more about cell biology and computational courses to expand my interests. After the focus on these different disciplines, I hope to know where I would like to focus on during my masters thesis in my second year.
- Alex Vasilevich, 2020, Data Scientist at BIS.
- Steven Vermeulen, 2020, PhD Student at MERLN institute: Engineering the tendon fibroblast micro-environment by surface topographies.
- Pascal Vroemen, 2019, PhD Student at cBITE (Cell Biology Inspired Tissue Engineering) and BiS (BioInterface Science in Regenerative Medicine
- Alex Vasilevich, 2018, PhD Student, Computational approach to engineer the interface between cells and biomaterials.
- Aurélie Carlier, 2018, Assistant Prof at cBITE (Cell Biology Inspired Tissue Engineering)
- Dennie Hebels, 2018, Project Manager at cBITE (Cell Biology Inspired Tissue Engineering)
- Marloes Kamphuis, 2018, Lab Manager at cBITE (Cell Biology Inspired Tissue Engineering)
- Nadia Roumans, 2018, Lab Technician at cBITE (Cell Biology Inspired Tissue Engineering)
- Linfeng (Joseph) Li, 2018, PhD student: Trophoblast stem cell differentiation via TopoChip Technology.
- Nick Beijer, 2018, PhD student: Topographically enhanced cell culture systems to induce and monitor mechanobiology.
- Frits Hulshof, 2016, PhD student: Topochip: Technology for Instructing Cell Fate and Morphology via Designed Surface Topography.
- Jenny Brinkmann, 2016, PhD student: Dynamic bioactive surfaces for cells using cucurbiturils.
- Maqsood (Max) Ahmed, 2014, postdoc: High-throughput screening of fiber spun scaffolds.
- Anouk Mentink, 2014, research technician and lab manager.
- Eelco Fennema, 2014, PhD student: An analysis of trauma and its solutions in bone tissue engineering.
- Bach Le Quang, 2014, PhD student:Decellularized cartilage matrix as an alternative for demineralized bone matrix.
- Nathalie Groen, 2014, PhD student: High throughput screening of bone graft materials.
- Vanessa LaPointe, 2014, postdoc: Molecular biology in 3D.
- Karolina Janeczek, 2013, PhD student: Endothelial differentiation of mesenchymal stem cells.
- Hemant Unadkat, 2012, PhD student: The effect of topography on cell behaviour.
- Joyce Doorn, 2012, PhD student: Paracrine signaling of human mesenchymal stem cells.
- Anindita Ganguly, 2012, PhD student: Clinical translation of bone tissue engineering.
- Ana Barradas, 2012, PhD student: Molecular mechanism of osteo-induction.
- Hugo Andre Alves, 2010, PhD student, Ageing and human mesenchymal stem cells.
- Jun Liu, 2009, PhD student, Bioluminescent imaging in tissue engineering.
- Jojanneke Jukes, 2009, PhD student, Embryonic stem cells in cartilage tissue engineering.
- Hugo Fernandes, 2009, PhD student and postdoc,The role of extracellular matrix in bone tissue engineering.
- Ram Siddappa, 2008, PhD student, Protein kinase A signaling in bone tissue engineering.
- Sanne Both, 2008, PhD student, Mouse embryonic stem cells in bone tissue engineering.
- Ruud Licht, 2007, research technician, Target discovery for bone-regeneration.
Tessa Warmink, 2020, Bachelor Thesis on the Role of Immune Response in Failure of Glaucoma Shunt Devices
- Marc Mazur, 2019, Master Student at BiS (BioInterface Science in Regenerative Medicine)
- Naomie Amsing, 2019: Difference in ERK activity in relation to cell cycle arrest as a response to surface topography.
- Nadia Takke, 2019: Differentiation of hMSCs into tenocyte-like cells on tendon-imprint topographies.
- Thomas Woud, 2019: Tendon-like surfaces influence tendon marker expression and cell alignment for tenogenic phenotype maintenance.
- Bas Voermans, 2019: Implementing Deep learning neural networks for prediction of cell count on TopoChip and correlation to topography induced proliferation.
- Niles Smolders,2019: The influence of micro topographies on SRC inhibition for early chondrogenic differentiation.
- Floris Honig, 2018: Assessing the expression level of mechanical sensitive markers on topographical surfaces.
- Fred Zhaoji Shen, 2018: Construction a computational model linking extracellular matrix properties to biomedical signaling pathway.
- Bianca Lourens, 2018: Imaging capabilities to explore possibilities in distinguishing monocytes from healthy donors and monocytes exposed to proinflammatory factors.
- Adrián Seijas Gamardo, 2018: Cell communication between mesenchymal stem cells and monocytes/macrophages
- Iris Wijnen, 2018: Mechanotransduction pathways involved in topography-induced cell behavior
- Francesca Bolk, 2018: Monocyte migration in response to proinflammatory factors
- Jingyun Wu, 2018: The response of flexor tendon derived cells to TGF-β2 exposure,
- Rianne Helgers, 2018: The response of flexor tendon derived cells to TGF-β2 exposure
- Zarina Nauryzgaliyeva, 2017: Braille code for cells: hMSCs protective response to cellular deformation induced by surface topographies
- Estela Arteaga, 2017: Study of the effect of topographies in human mesenchymal stem cells and cardiomyocyte size and proliferation
- Rika Reihs, 2017: Digitalizing life at the interface: Finding the missing links between biomaterial properties and biological pathways
- Ben van der Veer, 2017: Changing epigenetics with a Braille script for cells: The effect of micro topography on global histone acetylation and methylation in human mesenchymal stem cells
- Bram van Steen, 2017: Live Cell imaging reveals dynamic cell response to microstructured topographies
- Luc Sondorp, 2016: Gene regulatory effects of bone graft materials on osteoblasts
- Jéré van Lente, 2016: Topography screening with mesenchymal stem cells
Visiting scientist alumni
Giulia Sivelli, 2019, Department of Veterinary Clinical Sciences, Royal Veterinary College, UK
Laurence Burroughs, 2018, University of Nottingham, UK